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Sweepers in the CNS : Microglial Migration and Phagocytosis in the Alzheimer Disease Pathogenesis
Joint Authors
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Microglia are multifunctional immune cells in the central nervous system (CNS).
In the neurodegenerative diseases such as Alzheimer's disease (AD), accumulation of glial cells, gliosis, occurs in the lesions.
The role of accumulated microglia in the pathophysiology of AD is still controversial.
When neuronal damage occurs, microglia exert diversified functions, including migration, phagocytosis, and production of various cytokines and chemokines.
Among these, microglial phagocytosis of unwanted neuronal debris is critical to maintain the healthy neuronal networks.
Microglia express many surface receptors implicated in phagocytosis.
It has been suggested that the lack of microglial phagocytosis worsens pathology of AD and induces memory impairment.
The present paper summarizes recent evidences on implication of microglial chemotaxis and phagocytosis in AD pathology and discusses the mechanisms related to chemotaxis toward injured neurons and phagocytosis of unnecessary debris.
American Psychological Association (APA)
Noda, Mariko& Suzumura, Akio. 2012. Sweepers in the CNS : Microglial Migration and Phagocytosis in the Alzheimer Disease Pathogenesis. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-505799
Modern Language Association (MLA)
Noda, Mariko& Suzumura, Akio. Sweepers in the CNS : Microglial Migration and Phagocytosis in the Alzheimer Disease Pathogenesis. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-505799
American Medical Association (AMA)
Noda, Mariko& Suzumura, Akio. Sweepers in the CNS : Microglial Migration and Phagocytosis in the Alzheimer Disease Pathogenesis. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-505799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505799