HDL, Atherosclerosis, and Emerging Therapies
Joint Authors
Genest, Jacques
Hafiane, Anouar
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-28
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
This review aims to provide an overview on the properties of high-density lipoproteins (HDLs) and their cardioprotective effects.
Emergent HDL therapies will be presented in the context of the current understanding of HDL function, metabolism, and protective antiatherosclerotic properties.
The epidemiological association between levels of HDL-C or its major apolipoprotein (apoA-I) is strong, graded, and coherent across populations.
HDL particles mediate cellular cholesterol efflux, have antioxidant properties, and modulate vascular inflammation and vasomotor function and thrombosis.
A link of causality has been cast into doubt with Mendelian randomization data suggesting that genes causing HDL-C deficiency are not associated with increased cardiovascular risk, nor are genes associated with increased HDL-C, with a protective effect.
Despite encouraging data from small studies, drugs that increase HDL-C levels have not shown an effect on major cardiovascular end-points in large-scale clinical trials.
It is likely that the cholesterol mass within HDL particles is a poor biomarker of therapeutic efficacy.
In the present review, we will focus on novel therapeutic avenues and potential biomarkers of HDL function.
A better understanding of HDL antiatherogenic functions including reverse cholesterol transport, vascular protective and antioxidation effects will allow novel insight on novel, emergent therapies for cardiovascular prevention.
American Psychological Association (APA)
Hafiane, Anouar& Genest, Jacques. 2013. HDL, Atherosclerosis, and Emerging Therapies. Cholesterol،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-505832
Modern Language Association (MLA)
Hafiane, Anouar& Genest, Jacques. HDL, Atherosclerosis, and Emerging Therapies. Cholesterol No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-505832
American Medical Association (AMA)
Hafiane, Anouar& Genest, Jacques. HDL, Atherosclerosis, and Emerging Therapies. Cholesterol. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-505832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505832