Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer
Joint Authors
van der Zee, Ate G. J.
ten Hoor, Klaske A.
Daemen, Toos
Hollema, Harry
de Bock, Geertruida H.
Leffers, Ninke
Vermeij, Renee
de Graeff, Pauline
Lambeck, Annechien
Nijman, Hans Wilhelm
Source
Clinical and Developmental Immunology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The prognosis of epithelial ovarian cancer (EOC), the primary cause of death from gynaecological malignancies, has only modestly improved over the last decades.
Immunotherapeutic treatment using a cocktail of antigens has been proposed as a “universal” vaccine strategy.
We determined the expression of tumor antigens in the context of MHC class I expression in 270 primary tumor samples using tissue microarray.
Expression of tumor antigens p53, SP17, survivin, WT1, and NY-ESO-1 was observed in 120 (48.0%), 173 (68.9%), 208 (90.0%), 129 (56.3%), and 27 (11.0%) of 270 tumor specimens, respectively.
In 93.2% of EOC, at least one of the investigated tumor antigens was (over)expressed.
Expression of MHC class I was observed in 78.1% of EOC.
In 3 out 4 primary tumors, (over)expression of a tumor antigen combined with MHC class I was observed.
These results indicate that a multiepitope vaccine, comprising these antigens, could serve as a universal therapeutic vaccine for the vast majority of ovarian cancer patients.
American Psychological Association (APA)
Vermeij, Renee& Daemen, Toos& de Bock, Geertruida H.& de Graeff, Pauline& Leffers, Ninke& Lambeck, Annechien…[et al.]. 2010. Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer. Clinical and Developmental Immunology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-505844
Modern Language Association (MLA)
Vermeij, Renee…[et al.]. Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer. Clinical and Developmental Immunology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-505844
American Medical Association (AMA)
Vermeij, Renee& Daemen, Toos& de Bock, Geertruida H.& de Graeff, Pauline& Leffers, Ninke& Lambeck, Annechien…[et al.]. Potential Target Antigens for a Universal Vaccine in Epithelial Ovarian Cancer. Clinical and Developmental Immunology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-505844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505844