Posttransplant Metabolic Syndrome
Joint Authors
Siddiqui, M. Shadab
Sterling, Richard K.
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Metabolic syndrome (MS) is a cluster of metabolic derangements associated with insulin resistance and an increased risk of cardiovascular mortality.
MS has become a major health concern worldwide and is considered to be the etiology of the current epidemic of diabetes and cardiovascular disease.
In addition to cardiovascular disease, the presence of MS is also closely associated with other comorbidities including nonalcoholic fatty liver disease (NAFLD).
The prevalence of MS in patients with cirrhosis and end-stage liver disease is not well established and difficult to ascertain.
Following liver transplant, the prevalence of MS is estimated to be 44–58%.
The main factors associated with posttransplant MS are posttransplant diabetes, obesity, dyslipidemia, and hypertension.
In addition to developing NAFLD, posttransplant MS is associated with increased cardiovascular mortality that is 2.5 times that of the age- and sex-matched individuals.
Additionally, the presence of posttransplant MS has been associated with rapid progression to fibrosis in individuals transplanted for HCV cirrhosis.
There is an urgent need for well-designed prospective studies to fully delineate the natural history and risk factors associated with posttransplant MS.
Until then, early recognition, prevention, and treatment of its components are vital in improving outcomes in liver transplant recipients.
American Psychological Association (APA)
Siddiqui, M. Shadab& Sterling, Richard K.. 2012. Posttransplant Metabolic Syndrome. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505846
Modern Language Association (MLA)
Siddiqui, M. Shadab& Sterling, Richard K.. Posttransplant Metabolic Syndrome. International Journal of Hepatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-505846
American Medical Association (AMA)
Siddiqui, M. Shadab& Sterling, Richard K.. Posttransplant Metabolic Syndrome. International Journal of Hepatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505846