Malondialdehyde in Exhaled Breath Condensate as a Marker of Oxidative Stress in Different Pulmonary Diseases
Joint Authors
Costa, F.
Vagaggini, B.
Bacci, E.
Malagrinò, L.
Cianchetti, S.
Di Franco, A.
Paggiaro, P. L.
Novelli, F.
Dente, F. L.
Bartoli, M. L.
Melosini, L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Oxidative stress plays a role in the pathogenesis of many chronic inflammatory lung diseases.
Exhaled breath condensate (EBC) collection is a noninvasive method to investigate pulmonary oxidative stress biomarkers such as malondialdehyde (MDA).
Subjects and Methods.
We measured MDA levels in EBC in a large number of patients (N=194) with respiratory diseases: asthma (N=64), bronchiectasis (BE, N=19), chronic obstructive pulmonary disease (COPD, N=73), idiopathic pulmonary fibrosis (IPF, N=38).
Fourteen healthy nonsmoking subjects were included as controls.
Results.
Excluding IPF subjects, MDA levels were significantly higher in all disease groups than in control group.
MDA was significantly higher in COPD than asthmatic and BE subjects.
Among asthmatics, corticosteroids-treated subjects had lower MDA levels than untreated subjects.
COPD subjects showed an inverse correlation between MDA concentrations and FEV1% (rho: −0.24, P<.05).
Conclusions.
EBC-MDA is increased in subjects with chronic airway disorders, particularly in COPD, and it is related to FEV1 reduction.
American Psychological Association (APA)
Bartoli, M. L.& Novelli, F.& Costa, F.& Malagrinò, L.& Melosini, L.& Bacci, E.…[et al.]. 2011. Malondialdehyde in Exhaled Breath Condensate as a Marker of Oxidative Stress in Different Pulmonary Diseases. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-505863
Modern Language Association (MLA)
Bartoli, M. L.…[et al.]. Malondialdehyde in Exhaled Breath Condensate as a Marker of Oxidative Stress in Different Pulmonary Diseases. Mediators of Inflammation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-505863
American Medical Association (AMA)
Bartoli, M. L.& Novelli, F.& Costa, F.& Malagrinò, L.& Melosini, L.& Bacci, E.…[et al.]. Malondialdehyde in Exhaled Breath Condensate as a Marker of Oxidative Stress in Different Pulmonary Diseases. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-505863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505863