Currently Available Biomarkers and Strategies for the Validation of Novel Candidates for Neurochemical Dementia Diagnostics in Alzheimer’s Disease and Mild Cognitive Impairment
Author
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The number of people afflicted with Alzheimer’s disease (AD) and other types of dementing conditions has grown exponentially in the last decades.
This review focuses on the diagnostic role of the classic cerebrospinal fluid (CSF) biomarkers of neurochemical dementia diagnostics (NDD) and critically discusses potential strategies for the development and validation of novel potential candidates.
In some countries, NDD is already established as a routine diagnostic tool, used for the evaluation of patients with cognitive impairments.
On the other hand, preanalytical and technical issues, partly discussed in this paper, prevent NDD from the general acceptance worldwide.
Currently, two groups of biomarkers in the CSF are considered in NDD: amyloid β (Aβ) peptides and Tau proteins, including the hyperphosphorylated forms of the latter (pTau).
The analyses of these two groups of biomarkers can reveal pathologic alterations as early as twenty years before the onset of clinical symptoms.
In mild cognitive impairment (MCI), NDD can reliably predict which individuals are at risk of converting to AD.
The roles of biomarkers of amyloid β deposition in the brain tissue (including the CSF concentration of Aβ42) and biomarkers of neurodegeneration (including the CSF concentrations of Tau/pTau proteins) are reflected in the currently proposed diagnostic criteria for AD and MCI.
American Psychological Association (APA)
Lewczuk, Piotr. 2014. Currently Available Biomarkers and Strategies for the Validation of Novel Candidates for Neurochemical Dementia Diagnostics in Alzheimer’s Disease and Mild Cognitive Impairment. Advances in Geriatrics،Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-505868
Modern Language Association (MLA)
Lewczuk, Piotr. Currently Available Biomarkers and Strategies for the Validation of Novel Candidates for Neurochemical Dementia Diagnostics in Alzheimer’s Disease and Mild Cognitive Impairment. Advances in Geriatrics No. 2014 (2014), pp.1-15.
https://search.emarefa.net/detail/BIM-505868
American Medical Association (AMA)
Lewczuk, Piotr. Currently Available Biomarkers and Strategies for the Validation of Novel Candidates for Neurochemical Dementia Diagnostics in Alzheimer’s Disease and Mild Cognitive Impairment. Advances in Geriatrics. 2014. Vol. 2014, no. 2014, pp.1-15.
https://search.emarefa.net/detail/BIM-505868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505868