Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors
Joint Authors
Ortíz, José G.
Ramos-Vélez, Igmeris
Torres-Hernández, Bianca A.
Cordero-Hernández, José M.
Berríos-Cartagena, Nairimer
Del Valle-Mojica, Lisa M.
González-Medina, Giselle
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The effects of two valerian extracts (aqueous and hydroalcoholic) were investigated through [3H]Glutamate ([3H]Glu) and [3H]Fluorowillardine ([3H]FW) receptor binding assays using rat synaptic membranes in presence of different receptor ligands.
In addition, the extract stability was monitored spectrophotometrically.
Both extracts demonstrated interaction with ionotropic glutamate receptors (iGluRs).
However, the extracts displayed considerable differences in receptor selectivity.
The hydroalcoholic extract selectively interacted with quisqualic acid (QA), group I metabotropic glutamate receptor (mGluR) ligand, while the aqueous extract did not alter the binding of QA.
The stability of the extracts was examined during several weeks.
Freshly prepared extract inhibited 38–60% of [3H]FW binding (AMPA).
After 10 days, the aqueous extract inhibited 85% of [3H]FW binding while the hydroalcoholic extract markedly potentiated (200%) [3H]FW binding to AMPA receptors.
Thus, our results showed that factors such as extraction solvent and extract stability determine the selectivity for glutamate receptor (GluR) interactions.
American Psychological Association (APA)
Del Valle-Mojica, Lisa M.& Cordero-Hernández, José M.& González-Medina, Giselle& Ramos-Vélez, Igmeris& Berríos-Cartagena, Nairimer& Torres-Hernández, Bianca A.…[et al.]. 2010. Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-505874
Modern Language Association (MLA)
Del Valle-Mojica, Lisa M.…[et al.]. Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-505874
American Medical Association (AMA)
Del Valle-Mojica, Lisa M.& Cordero-Hernández, José M.& González-Medina, Giselle& Ramos-Vélez, Igmeris& Berríos-Cartagena, Nairimer& Torres-Hernández, Bianca A.…[et al.]. Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-505874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505874