Effect of 2,4-Thiazolidinedione on Limousin Cattle Growth and on Muscle and Adipose Tissue Metabolism
Joint Authors
Garza, J. D.
Yabuta, A.
Mora, O.
Dávalos, J. L.
Arévalo-Turrubiarte, M.
González-Dávalos, L.
Shimada, A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The main adipogenic transcription factor PPARγ possesses high affinity to 2,4-TZD, a member of the Thiazolidinedione family of insulin-sensitizing compounds used as adipogenic agents.
We evaluated 2,4-TZD’s effect on bovine growth and PPAR tissue expression.
Seventeen Limousin bulls (18 month-old; 350 kg body weight (BW)) were assigned into 2 treatments: control and 2,4-TZD (8 mg/70 kg BW) and were fed until bulls reached 500 kg BW.
They were weighed and their blood was sampled.
DNA, RNA, and protein were determined in liver; skeletal muscle; subcutaneous (SC), omental, perirenal adipose tissues (AT) to determine protein synthesis rate and cellular size.
Expression of PPAR mRNA was measured in liver and muscle (PPARα, -δ, and -γ) and SC adipose tissue (γ) by real-time PCR.
No significant differences were found (P>0.1) in weight gain, days on feed, and carcass quality.
Muscle synthesis was greater in controls (P<0.05); cell size was larger with 2,4-TZD (P<0.05).
PPARα, -δ, and -γ expressions with 2,4-TZD in liver were lower (P<0.01) than in muscle.
No differences were found for PPARγ mRNA expression in SCAT.
The results suggest the potential use of 2,4-TZD in beef cattle diets, because it improves AT differentiation, liver, and muscle fatty acid oxidation that, therefore, might improve energy efficiency.
American Psychological Association (APA)
Arévalo-Turrubiarte, M.& González-Dávalos, L.& Yabuta, A.& Garza, J. D.& Dávalos, J. L.& Mora, O.…[et al.]. 2012. Effect of 2,4-Thiazolidinedione on Limousin Cattle Growth and on Muscle and Adipose Tissue Metabolism. PPAR Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-505879
Modern Language Association (MLA)
Arévalo-Turrubiarte, M.…[et al.]. Effect of 2,4-Thiazolidinedione on Limousin Cattle Growth and on Muscle and Adipose Tissue Metabolism. PPAR Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-505879
American Medical Association (AMA)
Arévalo-Turrubiarte, M.& González-Dávalos, L.& Yabuta, A.& Garza, J. D.& Dávalos, J. L.& Mora, O.…[et al.]. Effect of 2,4-Thiazolidinedione on Limousin Cattle Growth and on Muscle and Adipose Tissue Metabolism. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-505879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505879