Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
Joint Authors
Bellini, Marilanda Ferreira
Cadamuro, Aline Cristina Targa
Silva, Ana Elizabete
Succi, Maysa
Proença, Marcela Alcântara
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
TP53 genes is one of more important tumor suppressor gene, which acts as a potent transcription factor with fundamental role in the maintenance of genetic stability.
The development of esophageal and gastric cancers is a multistep process resulting in successive accumulation of genetic alterations that culminates in the malignant transformation.
Thus, this study highlights the participation of the main genetic alterations of the TP53 gene in esophageal and gastric carcinogenesis.
Among these changes, high frequency of TP53 mutations, loss of heterozygosity (LOH), overexpression of the p53 protein, and consequently loss of p53 function, which would be early events in esophageal and gastric cancers, as well as an important biomarker of the prognosis and treatment response.
Furthermore, Single Nucleotide Polymorphisms (SNPs) of TP53 have been implicated in the development and prognosis of several cancers, mainly TP53 codon 72 polymorphism whose role has been extensively studied in relation to susceptibility for esophageal and gastric cancer development.
American Psychological Association (APA)
Bellini, Marilanda Ferreira& Cadamuro, Aline Cristina Targa& Succi, Maysa& Proença, Marcela Alcântara& Silva, Ana Elizabete. 2012. Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-505892
Modern Language Association (MLA)
Bellini, Marilanda Ferreira…[et al.]. Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-505892
American Medical Association (AMA)
Bellini, Marilanda Ferreira& Cadamuro, Aline Cristina Targa& Succi, Maysa& Proença, Marcela Alcântara& Silva, Ana Elizabete. Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-505892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505892