Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents
Joint Authors
Zhang, Mei-Xian
Cianflone, Katherine
Munkonda, Mercedes Nancy
Zhao, Xiao-Yuan
Mi, Jie
Fouejeu, Ponce Cedric Wamba
Li, Ming
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Objective.
To evaluate leptin and adiponectin as biomarkers of metabolic syndrome (MS) risk factors even in nonobese children/adolescents.
Methods.
Serum leptin, adiponectin, leptin:adiponectin ratio, lipids, glucose, and insulin concentrations as well as body size parameters and pubertal development were evaluated in a large population of Chinese children/adolescents (n=3505, 6–18 years, 1722 girls and 1783 boys).
Results.
Leptin concentration increased while adiponectin decreased with obesity, both were influenced by pubertal development.
Central obesity had an additive effect on leptin levels (above obesity alone).
Leptin/adiponectin increased 8.4-fold and 3.2-fold in overweight/obesity, and 15.8- and 4.5-fold with obesity plus MS, in early and late puberty, respectively.
Even in normal weight children/adolescents, higher leptin and lower adiponectin concentrations associated with increased risk profile.
Conversely, overweight/obese with lower leptin or higher adiponectin concentrations had a less compromised metabolic profile.
Conclusion.
Leptin, adiponectin, and leptin:adiponectin ratio are informative biomarkers for obesity, central obesity, MS, and abnormal metabolic profile even in normal weight children/adolescents.
American Psychological Association (APA)
Mi, Jie& Munkonda, Mercedes Nancy& Li, Ming& Zhang, Mei-Xian& Zhao, Xiao-Yuan& Fouejeu, Ponce Cedric Wamba…[et al.]. 2010. Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents. Journal of Obesity،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-505902
Modern Language Association (MLA)
Mi, Jie…[et al.]. Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents. Journal of Obesity No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-505902
American Medical Association (AMA)
Mi, Jie& Munkonda, Mercedes Nancy& Li, Ming& Zhang, Mei-Xian& Zhao, Xiao-Yuan& Fouejeu, Ponce Cedric Wamba…[et al.]. Adiponectin and Leptin Metabolic Biomarkers in Chinese Children and Adolescents. Journal of Obesity. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-505902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505902