β-Cell Generation : Can Rodent Studies Be Translated to Humans?
Joint Authors
Spijker, H. Siebe
Ellenbroek, Johanne H.
Hoeben, Rob C.
Zaldumbide, Arnaud
Carlotti, Françoise
de Koning, Eelco J.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
β-cell replacement by allogeneic islet transplantation is a promising approach for patients with type 1 diabetes, but the shortage of organ donors requires new sources of β cells.
Islet regeneration in vivo and generation of β-cells ex vivo followed by transplantation represent attractive therapeutic alternatives to restore the β-cell mass.
In this paper, we discuss different postnatal cell types that have been envisaged as potential sources for future β-cell replacement therapy.
The ultimate goal being translation to the clinic, a particular attention is given to the discrepancies between findings from studies performed in rodents (both ex vivo on primary cells and in vivo on animal models), when compared with clinical data and studies performed on human cells.
American Psychological Association (APA)
Carlotti, Françoise& Zaldumbide, Arnaud& Ellenbroek, Johanne H.& Spijker, H. Siebe& Hoeben, Rob C.& de Koning, Eelco J.. 2011. β-Cell Generation : Can Rodent Studies Be Translated to Humans?. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-505926
Modern Language Association (MLA)
Carlotti, Françoise…[et al.]. β-Cell Generation : Can Rodent Studies Be Translated to Humans?. Journal of Transplantation No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-505926
American Medical Association (AMA)
Carlotti, Françoise& Zaldumbide, Arnaud& Ellenbroek, Johanne H.& Spijker, H. Siebe& Hoeben, Rob C.& de Koning, Eelco J.. β-Cell Generation : Can Rodent Studies Be Translated to Humans?. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-505926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505926