Influence of Air Temperature and Humidity on Dehydration Equilibria and Kinetics of Theophylline
Joint Authors
Timoumi, Souad
Zagrouba, Fethi
Touil, Amira
Peczalski, Roman
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Economics & Business Administration
Pharmacology
Abstract EN
The effect of hygrothermal conditions (air temperature and relative humidity) on the dehydration of theophylline monohydrate was investigated.
Firstly, the equilibrium states of theophylline were investigated.
The data from gravimetric analysis at constant temperature and humidity were reported as desorption isotherms.
The PXRD analysis was used to identify the different polymorphic forms of theophylline: the monohydrate, the metastable anhydrate, and the stable anhydrate.
Solid-solid phase diagrams for two processing times were proposed.
Secondly, the dehydration kinetics were studied.
The water content evolutions with time were recorded at several temperatures from 20°C to 80°C and several relative humidities from 4% to 50%.
Different mathematical models were used to fit the experimental data.
The spatially averaged solution of 2D Fickian transient diffusion equation best represented the water mass loss versus time experimental relationship.
The dehydration rate constant was found to increase exponentially with air temperature and to decrease exponentially with air relative humidity.
American Psychological Association (APA)
Touil, Amira& Peczalski, Roman& Timoumi, Souad& Zagrouba, Fethi. 2012. Influence of Air Temperature and Humidity on Dehydration Equilibria and Kinetics of Theophylline. Journal of Pharmaceutics،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-505942
Modern Language Association (MLA)
Touil, Amira…[et al.]. Influence of Air Temperature and Humidity on Dehydration Equilibria and Kinetics of Theophylline. Journal of Pharmaceutics No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-505942
American Medical Association (AMA)
Touil, Amira& Peczalski, Roman& Timoumi, Souad& Zagrouba, Fethi. Influence of Air Temperature and Humidity on Dehydration Equilibria and Kinetics of Theophylline. Journal of Pharmaceutics. 2012. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-505942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505942