Inhibition of Arterial Allograft Intimal Hyperplasia Using Recipient Dendritic Cells Pretreated with B7 Antisense Peptide
Joint Authors
Wang, Xiaoxiao
Cai, Duan
Xiang, Jian-Bin
Zhou, Yi-Ming
Yao, Yu-Feng
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Low expression or absence of dendritic cell (DC) surface B7 molecules can induce immune tolerance or hyporesponse.
Whether DCs could induce indirect allogeneic-specific cross-tolerance or hyporesponse to recipient T cells remains unclear.
Methods.
Generated from C3H/He mice bone marrow cells pulsed with donor antigen from C57BL/6 mice, recipient DCs were incubated with B7 antisense peptide (B7AP).
Immune regulatory activities were examined in vitro by a series of mixed lymphocyte reactions.
Murine allogeneic carotid artery orthotopic transplantation was performed from C57BL/6 to C3H/He.
Recipients were given B7AP-treated DCs 7 days before transplantation.
Allograft pathological analysis was done 2 months after transplantation.
Results.
B7AP-pretreated DCs markedly inhibited T-cell proliferation compared with untreated group.
Pretreated T cells exhibited markedly reduced response to alloantigen versus third-party antigen.
Pathological analysis of arterial allografts demonstrated significant reduction of intimal hyperplasia in B7-AP pretreated group versus control.
Conclusion.
Blockade of B7 molecules by B7AP could induce indirect allogeneic-specific hyporesponse and inhibit arterial allograft intimal hyperplasia, which may be involved in future strategies for human allograft chronic rejection.
American Psychological Association (APA)
Yao, Yu-Feng& Zhou, Yi-Ming& Xiang, Jian-Bin& Wang, Xiaoxiao& Cai, Duan. 2012. Inhibition of Arterial Allograft Intimal Hyperplasia Using Recipient Dendritic Cells Pretreated with B7 Antisense Peptide. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-505947
Modern Language Association (MLA)
Yao, Yu-Feng…[et al.]. Inhibition of Arterial Allograft Intimal Hyperplasia Using Recipient Dendritic Cells Pretreated with B7 Antisense Peptide. Clinical and Developmental Immunology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-505947
American Medical Association (AMA)
Yao, Yu-Feng& Zhou, Yi-Ming& Xiang, Jian-Bin& Wang, Xiaoxiao& Cai, Duan. Inhibition of Arterial Allograft Intimal Hyperplasia Using Recipient Dendritic Cells Pretreated with B7 Antisense Peptide. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-505947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505947