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Quantifying Solid-State Mixtures of Crystalline Indomethacin by Raman Spectroscopy Comparison with Thermal Analysis
Joint Authors
Atef, Eman
Prasad, Dev
Kumari, Dunesh
Chauhan, Harsh
Pidgeon, Charles
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-06
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This paper investigates Raman spectroscopy as a quick and reliable method to quantify the alpha (α) and gamma (γ) polymorphic forms of indomethacin compared to differential scanning calorimetry (DSC).
Binary mixtures with different ratios of α and γ indomethacin were prepared and analyzed by Raman and DSC.
The Raman method was found to be more reliable and superior compared to DSC.
The partial conversion of the alpha to gamma polymorphic form during the DSC measurement was the major limitation for the use of full DSC as a quantitative method and resulted in difference between the calculated and measured enthalpy of both polymorphic forms.
American Psychological Association (APA)
Atef, Eman& Chauhan, Harsh& Prasad, Dev& Kumari, Dunesh& Pidgeon, Charles. 2012. Quantifying Solid-State Mixtures of Crystalline Indomethacin by Raman Spectroscopy Comparison with Thermal Analysis. ISRN Chromatography،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505957
Modern Language Association (MLA)
Atef, Eman…[et al.]. Quantifying Solid-State Mixtures of Crystalline Indomethacin by Raman Spectroscopy Comparison with Thermal Analysis. ISRN Chromatography No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-505957
American Medical Association (AMA)
Atef, Eman& Chauhan, Harsh& Prasad, Dev& Kumari, Dunesh& Pidgeon, Charles. Quantifying Solid-State Mixtures of Crystalline Indomethacin by Raman Spectroscopy Comparison with Thermal Analysis. ISRN Chromatography. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-505957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505957