Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat : A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities
Joint Authors
Chatterjee, Kausik
Ali, Kazi Monjur
De, Debasis
Bera, Tushar Kanti
Ghosh, Debidas
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-28
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Antidiabetic, antioxidative, and antihyperlipidemic activities of aqueous-methanolic (2 : 3) extract of Swietenia mahagoni (L.) Jacq.
(family Meliaceae) seed studied in streptozotocin-induced diabetic rats.
Feeding with seed extract (25 mg 0.25 mL distilled water−1100 gm b.w.−1rat−1 day−1) for 21 days to diabetic rat lowered the blood glucose level as well as the glycogen level in liver.
Moreover, activities of antioxidant enzymes like catalase, peroxidase, and levels of the products of free radicals like conjugated diene and thiobarbituric acid reactive substances in liver, kidney, and skeletal muscles were corrected towards the control after this extract treatment in this model.
Furthermore, the seed extract corrected the levels of serum urea, uric acid, creatinine, cholesterol, triglyceride, and lipoproteins towards the control level in this experimental diabetic model.
The results indicated the potentiality of the extract of S.
mahagoni seed for the correction of diabetes and its related complications like oxidative stress and hyperlipidemia.
The extract may be a good candidate for developing a safety, tolerable, and promising neutraceutical treatment for the management of diabetes.
American Psychological Association (APA)
De, Debasis& Chatterjee, Kausik& Ali, Kazi Monjur& Bera, Tushar Kanti& Ghosh, Debidas. 2010. Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat : A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-505958
Modern Language Association (MLA)
De, Debasis…[et al.]. Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat : A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-505958
American Medical Association (AMA)
De, Debasis& Chatterjee, Kausik& Ali, Kazi Monjur& Bera, Tushar Kanti& Ghosh, Debidas. Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat : A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-505958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505958