![](/images/graphics-bg.png)
Tumorigenic Factor CRIPTO-1 Is Immunolocalized in Extravillous Cytotrophoblast in Placenta Creta
Joint Authors
Zugaib, Marcelo
Pulcineli Vieira Francisco, Rossana
Bandeira, Carla Letícia
Bevilacqua, Estela
Schultz, Regina
Urban Borbely, Alexandre
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
CRIPTO-(CR)1 is a protein associated with tumorigenesis and metastasis.
Here we demonstrate that CR-1 expression in normal and creta placentas is associated with various degrees of uterine invasion.
Cytokeratin (CK) and CR-1 protein expression was visualized by immunohistochemical staining of formalin-fixed, paraffin-embedded placental specimens (control placentas, n=9; accreta, n=6; increta, n=10; percreta, n=15).
The pattern of extravillous trophoblast (EVT) cell morphology was distinctive in creta placentas: densely-compacted cell columns and large star-shaped cells with a typically migratory phenotype, not common among third trimester control placentas.
Quantification revealed higher CR-1 immunoreactivities in accreta (P=0.001), increta (P=0.0002), and percreta placentas (P=0.001) than in controls.
In contrast to controls, there was a significant positive relationship between CR-1 and CK reactivity in all creta placentas (accreta, P=0.02; increta, P=0.0001, and percreta, P=0.025).
This study demonstrated CR-1 expression in the placental bed, its increased expression in creta placentas, and EVT cells as the main CR-1-producing cell type.
Morphological examination revealed an immature and invasive trophoblast profile in creta placentas, suggesting impairment of the trophoblast differentiation pathway.
These findings provide important new insights into the pathophysiology of abnormal creta placentation and its gestational consequences.
American Psychological Association (APA)
Bandeira, Carla Letícia& Urban Borbely, Alexandre& Pulcineli Vieira Francisco, Rossana& Schultz, Regina& Zugaib, Marcelo& Bevilacqua, Estela. 2014. Tumorigenic Factor CRIPTO-1 Is Immunolocalized in Extravillous Cytotrophoblast in Placenta Creta. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-505963
Modern Language Association (MLA)
Bandeira, Carla Letícia…[et al.]. Tumorigenic Factor CRIPTO-1 Is Immunolocalized in Extravillous Cytotrophoblast in Placenta Creta. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-505963
American Medical Association (AMA)
Bandeira, Carla Letícia& Urban Borbely, Alexandre& Pulcineli Vieira Francisco, Rossana& Schultz, Regina& Zugaib, Marcelo& Bevilacqua, Estela. Tumorigenic Factor CRIPTO-1 Is Immunolocalized in Extravillous Cytotrophoblast in Placenta Creta. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-505963
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505963