Role of Adaptive Immunity in Alcoholic Liver Disease
Author
Source
International Journal of Hepatology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Stimulation of innate immunity is increasingly recognized to play an important role in the pathogenesis of alcoholic liver disease (ALD), while the contribution of adaptive immunity has received less attention.
Clinical and experimental data show the involvement of Th-1 and Th-17 T-lymphocytes in alcoholic hepatitis.
Nonetheless, the mechanisms by which alcohol triggers adaptive immunity are still incompletely characterized.
Patients with advanced ALD have circulating IgG and T-lymphocytes recognizing epitopes derived from protein modification by hydroxyethyl free radicals and end products of lipid-peroxidation.
High titers of IgG against lipid peroxidation-derived antigens are associated with an increased hepatic production of proinflammatory cytokines/chemokines.
Moreover, the same antigens favor the breaking of self-tolerance towards liver constituents.
In particular, autoantibodies against cytochrome P4502E1 (CYP2E1) are evident in a subset of ALD patients.
Altogether these results suggest that allo- and autoimmune reactions triggered by oxidative stress might contribute to hepatic inflammation during the progression of ALD.
American Psychological Association (APA)
Albano, Emanuele. 2011. Role of Adaptive Immunity in Alcoholic Liver Disease. International Journal of Hepatology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-505975
Modern Language Association (MLA)
Albano, Emanuele. Role of Adaptive Immunity in Alcoholic Liver Disease. International Journal of Hepatology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-505975
American Medical Association (AMA)
Albano, Emanuele. Role of Adaptive Immunity in Alcoholic Liver Disease. International Journal of Hepatology. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-505975
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505975