![](/images/graphics-bg.png)
The Multifaceted Functions of CXCL10 in Cardiovascular Disease
Joint Authors
van den Borne, Pleunie
Quax, Paul H. A.
Hoefer, Imo E.
Pasterkamp, Gerard
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
C-X-C motif ligand 10 (CXCL10), or interferon-inducible protein-10, is a small chemokine belonging to the CXC chemokine family.
Its members are responsible for leukocyte trafficking and act on tissue cells, like endothelial and vascular smooth muscle cells.
CXCL10 is secreted by leukocytes and tissue cells and functions as a chemoattractant, mainly for lymphocytes.
After binding to its receptor CXCR3, CXCL10 evokes a range of inflammatory responses: key features in cardiovascular disease (CVD).
The role of CXCL10 in CVD has been extensively described, for example for atherosclerosis, aneurysm formation, and myocardial infarction.
However, there seems to be a discrepancy between experimental and clinical settings.
This discrepancy occurs from differences in biological actions between species (e.g.
mice and human), which is dependent on CXCL10 signaling via different CXCR3 isoforms or CXCR3-independent signaling.
This makes translation from experimental to clinical settings challenging.
Furthermore, the overall consensus on the actions of CXCL10 in specific CVD models is not yet reached.
The purpose of this review is to describe the functions of CXCL10 in different CVDs in both experimental and clinical settings and to highlight and discuss the possible discrepancies and translational difficulties.
Furthermore, CXCL10 as a possible biomarker in CVD will be discussed.
American Psychological Association (APA)
van den Borne, Pleunie& Quax, Paul H. A.& Hoefer, Imo E.& Pasterkamp, Gerard. 2014. The Multifaceted Functions of CXCL10 in Cardiovascular Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-505987
Modern Language Association (MLA)
van den Borne, Pleunie…[et al.]. The Multifaceted Functions of CXCL10 in Cardiovascular Disease. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-505987
American Medical Association (AMA)
van den Borne, Pleunie& Quax, Paul H. A.& Hoefer, Imo E.& Pasterkamp, Gerard. The Multifaceted Functions of CXCL10 in Cardiovascular Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-505987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505987