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Longitudinal Evaluation of Fatty Acid Metabolism in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic MicroSPECT Imaging
Joint Authors
Boutchko, Rostyslav
Brennan, Kathleen M.
Huesman, Ronald H.
Gullberg, Grant T.
Hanrahan, Stephen M.
Reutter, Bryan W.
Source
International Journal of Molecular Imaging
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The goal of this project is to develop radionuclide molecular imaging technologies using a clinical pinhole SPECT/CT scanner to quantify changes in cardiac metabolism using the spontaneously hypertensive rat (SHR) as a model of hypertensive-related pathophysiology.
This paper quantitatively compares fatty acid metabolism in hearts of SHR and Wistar-Kyoto normal rats as a function of age and thereby tracks physiological changes associated with the onset and progression of heart failure in the SHR model.
The fatty acid analog, 123I-labeled BMIPP, was used in longitudinal metabolic pinhole SPECT imaging studies performed every seven months for 21 months.
The uniqueness of this project is the development of techniques for estimating the blood input function from projection data acquired by a slowly rotating camera that is imaging fast circulation and the quantification of the kinetics of 123I-BMIPP by fitting compartmental models to the blood and tissue time-activity curves.
American Psychological Association (APA)
Reutter, Bryan W.& Huesman, Ronald H.& Brennan, Kathleen M.& Boutchko, Rostyslav& Hanrahan, Stephen M.& Gullberg, Grant T.. 2010. Longitudinal Evaluation of Fatty Acid Metabolism in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic MicroSPECT Imaging. International Journal of Molecular Imaging،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-505989
Modern Language Association (MLA)
Reutter, Bryan W.…[et al.]. Longitudinal Evaluation of Fatty Acid Metabolism in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic MicroSPECT Imaging. International Journal of Molecular Imaging No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-505989
American Medical Association (AMA)
Reutter, Bryan W.& Huesman, Ronald H.& Brennan, Kathleen M.& Boutchko, Rostyslav& Hanrahan, Stephen M.& Gullberg, Grant T.. Longitudinal Evaluation of Fatty Acid Metabolism in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic MicroSPECT Imaging. International Journal of Molecular Imaging. 2010. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-505989
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505989