Role of Heparan Sulfate 2-O-Sulfotransferase in Prostate Cancer Cell Proliferation, Invasion, and Growth Factor Signaling
Joint Authors
Ferguson, Brent W.
Datta, Sumana
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Heparan-sulfate proteoglycans (HSPGs) are required for maximal growth factor signaling in prostate cancer progression.
The degree of sulfate modification on the covalently attached heparan sulfate (HS) chains is one of the determining factors of growth factor-HSPG interactions.
Sulfate groups are transferred to HS chains via a series of O-sulfotransferases.
In the present study, we demonstrate that Heparan sulfate 2-O-sulfotransferase (2OST) is essential for maximal proliferation and invasion of prostate cancer cells in the LNCaP-C4-2B model.
We also show that a decrease in invasion due to 2OST siRNA is associated with an increase in actin and E-cadherin accumulation at the cell surface.
2OST expression correlates with increasing metastatic potential in this model.
We demonstrate that 2OST expression is upregulated by the stress-inducible transcription factors HIF1α, ATF2, and NFκB.
Chromatin immunoprecipitation analysis suggests that HIF1α and ATF2 act directly on the 2OST promoter, while NFκB acts indirectly.
American Psychological Association (APA)
Ferguson, Brent W.& Datta, Sumana. 2011. Role of Heparan Sulfate 2-O-Sulfotransferase in Prostate Cancer Cell Proliferation, Invasion, and Growth Factor Signaling. Prostate Cancer،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-506002
Modern Language Association (MLA)
Ferguson, Brent W.& Datta, Sumana. Role of Heparan Sulfate 2-O-Sulfotransferase in Prostate Cancer Cell Proliferation, Invasion, and Growth Factor Signaling. Prostate Cancer No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-506002
American Medical Association (AMA)
Ferguson, Brent W.& Datta, Sumana. Role of Heparan Sulfate 2-O-Sulfotransferase in Prostate Cancer Cell Proliferation, Invasion, and Growth Factor Signaling. Prostate Cancer. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-506002
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506002