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Human Papillomavirus Genotyping and E6E7 mRNA Expression in Greek Women with Intraepithelial Neoplasia and Squamous Cell Carcinoma of the Vagina and Vulva
Joint Authors
Apostolaki, Aikaterini
Papassideri, Issidora
Magiakos, George
Argyri, Elena
Panotopoulou, Efstathia
Kouvousi, Maria
Michala, Lina
Tsimplaki, Elpida
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
A large proportion of vaginal and vulvar squamous cell carcinomas (SCCs) and intraepithelial neoplasias (VAIN and VIN) are associated with HPV infection, mainly type 16.
The purpose of this study was to identify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33, and 45) in 56 histology samples of VAIN, VIN, vaginal, and vulvar SCCs.
HPV was identified in 56% of VAIN and 50% of vaginal SCCs, 71.4% of VIN and 50% of vulvar SCCs.
E6/E7 mRNA expression was found in one-third of VAIN and in all vaginal SCCs, 42.9% of VIN and 83.3% of vulvar SCCs.
Our data indicated that HPV 16 was the commonest genotype identified in VAIN and VIN and the only genotype found in SCCs of the vagina and vulva.
These findings may suggest, in accordance with other studies, that mRNA assay might be useful in triaging lesions with increased risk of progression to cancer.
American Psychological Association (APA)
Tsimplaki, Elpida& Argyri, Elena& Michala, Lina& Kouvousi, Maria& Apostolaki, Aikaterini& Magiakos, George…[et al.]. 2011. Human Papillomavirus Genotyping and E6E7 mRNA Expression in Greek Women with Intraepithelial Neoplasia and Squamous Cell Carcinoma of the Vagina and Vulva. Journal of Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-506012
Modern Language Association (MLA)
Tsimplaki, Elpida…[et al.]. Human Papillomavirus Genotyping and E6E7 mRNA Expression in Greek Women with Intraepithelial Neoplasia and Squamous Cell Carcinoma of the Vagina and Vulva. Journal of Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-506012
American Medical Association (AMA)
Tsimplaki, Elpida& Argyri, Elena& Michala, Lina& Kouvousi, Maria& Apostolaki, Aikaterini& Magiakos, George…[et al.]. Human Papillomavirus Genotyping and E6E7 mRNA Expression in Greek Women with Intraepithelial Neoplasia and Squamous Cell Carcinoma of the Vagina and Vulva. Journal of Oncology. 2011. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-506012
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506012