Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation
Joint Authors
Maturana, Carola J.
Harcha, Paloma A.
Sáez, Juan C.
Aguirre, Adam
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-02
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
In the central nervous system (CNS), mastocytes and glial cells (microglia, astrocytes and oligodendrocytes) function as sensors of neuroinflammatory conditions, responding to stress triggers or becoming sensitized to subsequent proinflammatory challenges.
The corticotropin-releasing hormone and glucocorticoids are critical players in stress-induced mastocyte degranulation and potentiation of glial inflammatory responses, respectively.
Mastocytes and glial cells express different toll-like receptor (TLR) family members, and their activation via proinflammatory molecules can increase the expression of connexin hemichannels and pannexin channels in glial cells.
These membrane pores are oligohexamers of the corresponding protein subunits located in the cell surface.
They allow ATP release and Ca2+ influx, which are two important elements of inflammation.
Consequently, activated microglia and astrocytes release ATP and glutamate, affecting myelinization, neuronal development, and survival.
Binding of ligands to TLRs induces a cascade of intracellular events leading to activation of several transcription factors that regulate the expression of many genes involved in inflammation.
During pregnancy, the previous responses promoted by viral infections and other proinflammatory conditions are common and might predispose the offspring to develop psychiatric disorders and neurological diseases.
Such disorders could eventually be potentiated by stress and might be part of the etiopathogenesis of CNS dysfunctions including autism spectrum disorders and schizophrenia.
American Psychological Association (APA)
Aguirre, Adam& Maturana, Carola J.& Harcha, Paloma A.& Sáez, Juan C.. 2013. Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-506029
Modern Language Association (MLA)
Aguirre, Adam…[et al.]. Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation. Mediators of Inflammation No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-506029
American Medical Association (AMA)
Aguirre, Adam& Maturana, Carola J.& Harcha, Paloma A.& Sáez, Juan C.. Possible Involvement of TLRs and Hemichannels in Stress-Induced CNS Dysfunction via Mastocytes, and Glia Activation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-506029
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506029