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Pathobiochemical Changes in Diabetic Skeletal Muscle as Revealed by Mass-Spectrometry-Based Proteomics
Author
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Insulin resistance in skeletal muscle tissues and diabetes-related muscle weakness are serious pathophysiological problems of increasing medical importance.
In order to determine global changes in the protein complement of contractile tissues due to diabetes mellitus, mass-spectrometry-based proteomics has been applied to the investigation of diabetic muscle.
This review summarizes the findings from recent proteomic surveys of muscle preparations from patients and established animal models of type 2 diabetes.
The potential impact of novel biomarkers of diabetes, such as metabolic enzymes and molecular chaperones, is critically examined.
Disease-specific signature molecules may be useful for increasing our understanding of the molecular and cellular mechanisms of insulin resistance and possibly identify new therapeutic options that counteract diabetic abnormalities in peripheral organ systems.
Importantly, the biomedical establishment of biomarkers promises to accelerate the development of improved diagnostic procedures for characterizing individual stages of diabetic disease progression, including the early detection of prediabetic complications.
American Psychological Association (APA)
Ohlendieck, Kay. 2012. Pathobiochemical Changes in Diabetic Skeletal Muscle as Revealed by Mass-Spectrometry-Based Proteomics. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-506057
Modern Language Association (MLA)
Ohlendieck, Kay. Pathobiochemical Changes in Diabetic Skeletal Muscle as Revealed by Mass-Spectrometry-Based Proteomics. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-506057
American Medical Association (AMA)
Ohlendieck, Kay. Pathobiochemical Changes in Diabetic Skeletal Muscle as Revealed by Mass-Spectrometry-Based Proteomics. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-506057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506057