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The Cancer Stem Cell Concept in Progression of Head and Neck Cancer
Author
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-03
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Human head and neck cancer (HNC) is a highly heterogeneous disease.
Understanding the biology of HNC progression is necessary for the development of novel approaches to its prevention, early detection, and treatment.
A current evolutional progression model has limitations in explaining the heterogeneity observed in a single tumor nest.
Accumulating evidence supports the existence of cancer stem cells (CSCs) as small subpopulations in solid tumors, including HNC.
These CSCs can be selected by appropriate cell surface markers, which are cancer type specific and have been confirmed by unique in vitro and in vivo assays.
Selected CSC populations maintain a self-renewal capability and show aggressive behaviors, such as chemoresistance and metastasis.
In addition to introducing the CSC concept in solid tumors, this short review summarizes current publications in HNC CSC and the prospective development and application of the CSC concept to HNC in the clinic.
American Psychological Association (APA)
Chen, Zhuo (Georgia). 2009. The Cancer Stem Cell Concept in Progression of Head and Neck Cancer. Journal of Oncology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-506079
Modern Language Association (MLA)
Chen, Zhuo (Georgia). The Cancer Stem Cell Concept in Progression of Head and Neck Cancer. Journal of Oncology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-506079
American Medical Association (AMA)
Chen, Zhuo (Georgia). The Cancer Stem Cell Concept in Progression of Head and Neck Cancer. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-506079
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506079