QCLAS and CRDS-Based CO Quantification as Aimed at in Breath Measurements
Joint Authors
Hering, Peter
Nwaboh, Javis Anyangwe
Werhahn, Olav
Heinrich, Kathrin
Persijn, Stefan
Sowa, Marcus
Source
International Journal of Spectroscopy
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Laser-spectrometric methods to derive absolute and traceable carbon monoxide (CO) amount fractions in exhaled human breath could be of advantage for early disease detection as well as for treatment monitoring.
As proof-of-principle laboratory experiment, we employed intra-pulse and continuous wave (cw) quantum cascade laser spectroscopy (QCLAS), both at 4.6 μm.
Additional experiments were carried out applying cw cavity ring-down spectroscopy (CRDS) with a CO sideband laser and a QCL.
We emphasize metrological data quality objectives, thatis, traceability and uncertainty, which could serve as essential benefits to exhaled breath measurements.
The results were evaluated and compared on a 100 μmol/mol CO level using the two QCLAS spectrometers, and the cw CO sideband laser CRDS setup.
The relative standard uncertainties of the pulsed and the cw QCLAS CO amount fraction results were ±4.8 and ±2.8%, respectively, that from the CO sideband laser CRDS was ±2.7%.
Sensitivities down to a 3 nmol/mol CO level were finally demonstrated and quantified by means of cw CRDS equipped with a QCL yielding standard uncertainties of about ±2.5 that are exclusively limited by the available line strength figure quality.
With this study we demonstrate the achieved comparability of CO quantifications, adhering metrological principles.
American Psychological Association (APA)
Nwaboh, Javis Anyangwe& Persijn, Stefan& Heinrich, Kathrin& Sowa, Marcus& Hering, Peter& Werhahn, Olav. 2012. QCLAS and CRDS-Based CO Quantification as Aimed at in Breath Measurements. International Journal of Spectroscopy،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-506137
Modern Language Association (MLA)
Nwaboh, Javis Anyangwe…[et al.]. QCLAS and CRDS-Based CO Quantification as Aimed at in Breath Measurements. International Journal of Spectroscopy No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-506137
American Medical Association (AMA)
Nwaboh, Javis Anyangwe& Persijn, Stefan& Heinrich, Kathrin& Sowa, Marcus& Hering, Peter& Werhahn, Olav. QCLAS and CRDS-Based CO Quantification as Aimed at in Breath Measurements. International Journal of Spectroscopy. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-506137
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506137