MicroRNAs and Alzheimer's Disease Mouse Models : Current Insights and Future Research Avenues
Joint Authors
Hébert, Sébastien S.
Delay, Charlotte
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Evidence from clinical trials as well as from studies performed in animal models suggest that both amyloid and tau pathologies function in concert with other factors to cause the severe neurodegeneration and dementia in Alzheimer’s disease (AD) patients.
Accumulating data in the literature suggest that microRNAs (miRNAs) could be such factors.
These conserved, small nonprotein-coding RNAs are essential for neuronal function and survival and have been implicated in the regulation of key genes involved in genetic and sporadic AD.
The study of miRNA changes in AD mouse models provides an appealing approach to address the cause-consequence relationship between miRNA dysfunction and AD pathology in humans.
Mouse models also provide attractive tools to validate miRNA targets in vivo and provide unique platforms to study the role of specific miRNA-dependent gene pathways in disease.
Finally, mouse models may be exploited for miRNA diagnostics in the fight against AD.
American Psychological Association (APA)
Delay, Charlotte& Hébert, Sébastien S.. 2011. MicroRNAs and Alzheimer's Disease Mouse Models : Current Insights and Future Research Avenues. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-506149
Modern Language Association (MLA)
Delay, Charlotte& Hébert, Sébastien S.. MicroRNAs and Alzheimer's Disease Mouse Models : Current Insights and Future Research Avenues. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-506149
American Medical Association (AMA)
Delay, Charlotte& Hébert, Sébastien S.. MicroRNAs and Alzheimer's Disease Mouse Models : Current Insights and Future Research Avenues. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-506149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506149