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Triggering DTH and CTL Activity by fd Filamentous Bacteriophages : Role of CD4+ T Cells in Memory Responses
Joint Authors
Barba, Pasquale
D'Apice, Luciana
Mascolo, Dina
De Berardinis, Piergiuseppe
Del Pozzo, Giovanna
Sartorius, Rossella
Citro, Alessandra
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The ability of fd bacteriophage particles to trigger different arms of the immune system has been previously shown by us with particular emphasis on the ability of phages to raise CTL responses in vitro and in vivo.
Here we show that fd virions in the absence of adjuvants are able to evoke a DTH reaction mediated by antigen specific CD8+ T cells.
In addition, we analyzed the induction of CTL responses in mice depleted of CD4+ T cells, and we observed that short-term secondary CTL responses were induced in the absence of CD4+ T cells while induction of long-term memory CTLs required the presence of CD4+ T lymphocytes.
These results examine the cellular mechanism at the basis of fd efficiency and provide new elements to further validate the use of fd particles for eliciting and monitoring antigen-specific CTLs.
American Psychological Association (APA)
Del Pozzo, Giovanna& Mascolo, Dina& Sartorius, Rossella& Citro, Alessandra& Barba, Pasquale& D'Apice, Luciana…[et al.]. 2010. Triggering DTH and CTL Activity by fd Filamentous Bacteriophages : Role of CD4+ T Cells in Memory Responses. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-506154
Modern Language Association (MLA)
Del Pozzo, Giovanna…[et al.]. Triggering DTH and CTL Activity by fd Filamentous Bacteriophages : Role of CD4+ T Cells in Memory Responses. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-506154
American Medical Association (AMA)
Del Pozzo, Giovanna& Mascolo, Dina& Sartorius, Rossella& Citro, Alessandra& Barba, Pasquale& D'Apice, Luciana…[et al.]. Triggering DTH and CTL Activity by fd Filamentous Bacteriophages : Role of CD4+ T Cells in Memory Responses. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-506154
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506154