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Suppression of Tumorigenesis : Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation
Joint Authors
Urbanska, Aleksandra Malgorzata
Prakash, Satya
Bhathena, Jasmine
Paul, Arghya
Source
International Journal of Inflammation
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective of this study was to examine the ability of a novel microencapsulated probiotic yogurt formulation to suppress the intestinal inflammation.
We assessed its anticancer activity by screening interleukin-1, 6, and 12 (IL-1, 6, 12), secretory levels of tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), prostaglandin E2 (PGE2), and thromboxane B2 in the digesta obtained from the duodenum, jejunum, proximal, and distal segments of the ileum of C57BL/6J-ApcMin/J mice.
Formulation-receiving animals showed consistently lower proinflammatory cytokines' levels when compared to control group animals receiving empty alginate-poly-L-lysine-alginate (APA) microcapsules suspended in saline.
The concentrations of IL-12 found in serum in control and treatment group animals were significant: 46.58±16.96 pg/mL and 158.58±28.56 pg/mL for control and treatment animals, respectively.
We determined a significant change in plasma C-reactive protein: 81.04±23.73 ng/mL in control group and 64.21±16.64 ng/mL in treatment group.
Western blots showed a 71% downregulation of cyclooxygenase-2 (COX-2) protein in treatment group animals compared to control.
These results point to the possibility of using this yogurt formulation in anticancer therapies, in addition to chronic gut diseases such as Crohn's disease, irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD) thanks to its inflammation lowering properties.Erratum of “Suppression of Tumorigenesis: Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation”dx.doi.org/10.4061/2011/891015
American Psychological Association (APA)
Urbanska, Aleksandra Malgorzata& Paul, Arghya& Bhathena, Jasmine& Prakash, Satya. 2011. Suppression of Tumorigenesis : Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation. International Journal of Inflammation،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-506155
Modern Language Association (MLA)
Urbanska, Aleksandra Malgorzata…[et al.]. Suppression of Tumorigenesis : Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation. International Journal of Inflammation No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-506155
American Medical Association (AMA)
Urbanska, Aleksandra Malgorzata& Paul, Arghya& Bhathena, Jasmine& Prakash, Satya. Suppression of Tumorigenesis : Modulation of Inflammatory Cytokines by Oral Administration of Microencapsulated Probiotic Yogurt Formulation. International Journal of Inflammation. 2011. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-506155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506155