Renal Effects of DPP-4 Inhibitors : A Focus on Microalbuminuria
Joint Authors
Frolík, Jan
Rychlík, Ivan
Haluzík, Martin
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Incretin-based therapies represent one of the most promising options in type 2 diabetes treatment owing to their good effectiveness with low risk of hypoglycemia and no weight gain.
Other numerous potential beneficial effects of incretin-based therapies have been suggested based mostly on experimental and small clinical studies including its beta-cell- and vasculo-protective actions.
One of the recently emerged interesting features of dipeptidyl peptidase-4 (DPP-4) inhibitors is its possible protective effect on the diabetic kidney disease.
Here, we review the renal effects of DPP-4 inhibitors with special focus on its influence on the onset and progression of microalbuminuria, as presence of microalbuminuria represents an important early sign of kidney damage and is also associated with increased risk of hypoglycemia and cardiovascular complications.
Mechanisms underlying possible nephroprotective properties of DPP-4 inhibitors include reduction of oxidative stress and inflammation and improvement of endothelial dysfunction.
Effects of DPP-4 inhibitors may be both glucagon-like peptide-1 (GLP-1) dependent and independent.
Ongoing prospective studies focused on the nephroprotective effects of DPP-4 inhibitors will further clarify its possible role in the prevention/attenuation of diabetic kidney disease beyond its glucose lowering properties.
American Psychological Association (APA)
Haluzík, Martin& Frolík, Jan& Rychlík, Ivan. 2013. Renal Effects of DPP-4 Inhibitors : A Focus on Microalbuminuria. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-506167
Modern Language Association (MLA)
Haluzík, Martin…[et al.]. Renal Effects of DPP-4 Inhibitors : A Focus on Microalbuminuria. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-506167
American Medical Association (AMA)
Haluzík, Martin& Frolík, Jan& Rychlík, Ivan. Renal Effects of DPP-4 Inhibitors : A Focus on Microalbuminuria. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-506167
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506167