Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats
Joint Authors
Georgopoulos, Panos G.
Sasso, Alan F.
Krishnan, Kannan
Isukapalli, Sastry S.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
A lipid-based physiologically based toxicokinetic (PBTK) model has been developed for a mixture of six polychlorinated biphenyls (PCBs) in rats.
The aim of this study was to apply population Bayesian analysis to a lipid PBTK model, while incorporating an internal exposure-response model linking enzyme induction and metabolic rate.
Lipid-based physiologically based toxicokinetic models are a subset of PBTK models that can simulate concentrations of highly lipophilic compounds in tissue lipids, without the need for partition coefficients.
A hierarchical treatment of population metabolic parameters and a CYP450 induction model were incorporated into the lipid-based PBTK framework, and Markov-Chain Monte Carlo was applied to in vivo data.
A mass balance of CYP1A and CYP2B in the liver was necessary to model PCB metabolism at high doses.
The linked PBTK/induction model remained on a lipid basis and was capable of modeling PCB concentrations in multiple tissues for all dose levels and dose profiles.
American Psychological Association (APA)
Sasso, Alan F.& Georgopoulos, Panos G.& Isukapalli, Sastry S.& Krishnan, Kannan. 2012. Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-506190
Modern Language Association (MLA)
Sasso, Alan F.…[et al.]. Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats. Journal of Toxicology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-506190
American Medical Association (AMA)
Sasso, Alan F.& Georgopoulos, Panos G.& Isukapalli, Sastry S.& Krishnan, Kannan. Bayesian Analysis of a Lipid-Based Physiologically Based Toxicokinetic Model for a Mixture of PCBs in Rats. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-506190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506190