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E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer : A Proof-of-Concept Study
Joint Authors
Yuvaraj, Saravanan
Somasundaram, Rajesh
Figaroa, Patrick A.
Bos, Nicolaas A.
al-Lahham, Sa’ad H.
Peppelenbosch, Maikel P.
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Colon cancer is a serious health problem, and novel preventive and therapeutical avenues are urgently called for.
Delivery of proteins with anticancer activity through genetically modified bacteria provides an interesting, potentially specific, economic and effective approach here.
Interestingly, bone morphogenetic protein 2 (BMP-2) is an important and powerful tumour suppressor in the colon and is thus an attractive candidate protein for delivery through genetically modified bacteria.
It has not been shown, however, that BMP production in the bacterial context is effective on colon cancer cells.
Here we demonstrate that transforming E.
coli with a cDNA encoding an ileal-derived mature human BMP-2 induces effective apoptosis in an in vitro model system for colorectal cancer, whereas the maternal organism was not effective in this respect.
Furthermore, these effects were sensitive to cotreatment with the BMP inhibitor Noggin.
We propose that prevention and treatment of colorectal cancer using transgenic bacteria is feasible.
American Psychological Association (APA)
Yuvaraj, Saravanan& al-Lahham, Sa’ad H.& Somasundaram, Rajesh& Figaroa, Patrick A.& Peppelenbosch, Maikel P.& Bos, Nicolaas A.. 2012. E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer : A Proof-of-Concept Study. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-506196
Modern Language Association (MLA)
Yuvaraj, Saravanan…[et al.]. E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer : A Proof-of-Concept Study. Gastroenterology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-506196
American Medical Association (AMA)
Yuvaraj, Saravanan& al-Lahham, Sa’ad H.& Somasundaram, Rajesh& Figaroa, Patrick A.& Peppelenbosch, Maikel P.& Bos, Nicolaas A.. E. coli-Produced BMP-2 as a Chemopreventive Strategy for Colon Cancer : A Proof-of-Concept Study. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-506196
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506196