Effects of Vitamin D Plus Calcium Supplements on Pharmacokinetics of Isoflavones in Thai Postmenopausal Women
Joint Authors
Sangdee, Chaichan
Rojanasthien, Noppamas
Teekachunhatean, Supanimit
Manorot, Maleeya
Pongnad, Paveena
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The objective of this study was to determine the effects of vitamin D3 plus calcium supplements (D3-calcium) on pharmacokinetics of isoflavones in Thai postmenopausal women.
This study was an open-labeled, randomized three-phase crossover study.
Twelve healthy subjects were randomized to receive one of the following regimens: (a) a single dose of isoflavones, (b) a single dose of isoflavones, and D3-calcium, or (c) continuous D3-calcium for 7 days followed by a single dose of isoflavones on the 8th day.
After a washout period, subjects were switched to receive the 2 remaining regimens according to their randomized sequences.
Blood samples were collected before dose and at specific time points until 32 hours after isoflavone administration.
Plasma was treated with β-glucuronidase/sulfatase to hydrolyze glucuronide and sulfate conjugates of daidzein and genistein.
Plasma concentrations of daidzein and genistein were determined by high performance liquid chromatography.
The estimated pharmacokinetic parameters of isoflavones were time to maximal plasma concentration (Tmax), maximal plasma concentration (Cmax), half-life (t1/2) and area under the plasma concentration-time curve (AUC).
Tmax of daidzein and genistein after regimen B was significantly longer than that of regimen A.
Other pharmacokinetic parameters of daidzein and genistein obtained following the three regimens were not significantly different.
American Psychological Association (APA)
Teekachunhatean, Supanimit& Pongnad, Paveena& Rojanasthien, Noppamas& Manorot, Maleeya& Sangdee, Chaichan. 2011. Effects of Vitamin D Plus Calcium Supplements on Pharmacokinetics of Isoflavones in Thai Postmenopausal Women. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-506200
Modern Language Association (MLA)
Teekachunhatean, Supanimit…[et al.]. Effects of Vitamin D Plus Calcium Supplements on Pharmacokinetics of Isoflavones in Thai Postmenopausal Women. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-506200
American Medical Association (AMA)
Teekachunhatean, Supanimit& Pongnad, Paveena& Rojanasthien, Noppamas& Manorot, Maleeya& Sangdee, Chaichan. Effects of Vitamin D Plus Calcium Supplements on Pharmacokinetics of Isoflavones in Thai Postmenopausal Women. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-506200
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506200