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Invariant NKT Cell Lines Derived from the NOD⋅H2h4 Mouse Enhance Autoimmune Thyroiditis
Joint Authors
Fan, Xiaoguang
Caturegli, Patrizio
Sharma, Rajni B.
Burek, C. Lynne
Rose, Noel R.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
To study the role of invariant Natural Killer T cell ( iNKT) cells in autoimmune thyroiditis, we derived two iNKT cell lines from the spleens of NOD⋅ H2h4 mice, a strain that develops spontaneous autoimmune thyroiditis exacerbated by excess dietary iodine.
The two lines were CD1d-restricted and expressed CD4+, DX5+, and the Vα4Jα281 gene segment, of the T-cell receptor α locus.
Upon stimulation with α-galactosyl-ceramide (α-GalCer), both lines rapidly produced IL-2, IL-4, IFN-γ, IL-10, and TNF-α.
Strikingly, a similar cytokine response was also induced by thyroglobulin, one of the most abundant protein in the thyroid gland and a major autoantigen in human autoimmune thyroiditis.
Transfer of the iNKT cell lines to syngeneic hosts enhanced autoimmune thyroiditis.
Intraperitoneal injections of α-GalCer in iodine primed mice also induced thyroid disease.
This paper reports for the first time that iNKT cells respond to thyroglobulin and enhance autoimmune thyroiditis in iodine fed NOD⋅H2h4 mice.
American Psychological Association (APA)
Sharma, Rajni B.& Fan, Xiaoguang& Caturegli, Patrizio& Rose, Noel R.& Burek, C. Lynne. 2011. Invariant NKT Cell Lines Derived from the NOD⋅H2h4 Mouse Enhance Autoimmune Thyroiditis. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-506226
Modern Language Association (MLA)
Sharma, Rajni B.…[et al.]. Invariant NKT Cell Lines Derived from the NOD⋅H2h4 Mouse Enhance Autoimmune Thyroiditis. Journal of Thyroid Research No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-506226
American Medical Association (AMA)
Sharma, Rajni B.& Fan, Xiaoguang& Caturegli, Patrizio& Rose, Noel R.& Burek, C. Lynne. Invariant NKT Cell Lines Derived from the NOD⋅H2h4 Mouse Enhance Autoimmune Thyroiditis. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-506226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506226