A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices
Joint Authors
Tian, Cindy
Rees, Gareth D.
Du, Min Quan
Barlow, Ashley P.
Mason, Stephen C.
Jiang, Han
Jeffery, Peter
Tai, Bao-Jun
He, Jane
Source
International Journal of Dentistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
A comparison of the desensitising efficacy of two commercially available dentifrices with different modes of action was conducted in a randomised, examiner-blind, two-arm, parallel group, 8-week, longitudinal clinical study.
Dentifrice A, (Sensodyne Multi Action Iso-Active), contained 50000 ppm KNO3 and 1450 ppm fluoride as NaF.
Dentifrice B, Colgate Sensitive Pro-Relief, contained a combination of 80000 ppm arginine, bicarbonate, calcium carbonate, and 1450 ppm fluorine as NaMFP.
Subjects (N=110), stratified into two groups (N=55), brushed twice-daily for 60 s, over an 8-week period.
Sensitivity status, compliance, and safety were determined at 1, 2, 4, and 8 weeks.
A fixed-effects ANCOVA statistical model was applied to the Intent-To-Treat population using a two-sided 5% significance level.
After 8 weeks, the treatment groups using Dentifrice A and Dentifrice B exhibited mean reductions from baseline of 49% and 45% in air sensitivity visual analogue scale (VAS) score, 61% (both) in examiner-based Schiff Sensitivity score, and clinically significant reductions in tactile pain threshold; all reductions were statistically significant (P<0.0001).
Both treatment groups also exhibited significant reductions across all sensitivity measures at 1, 2, and 4 weeks (P≤0.0059, Dentifrice A; P≤0.0137, Dentifrice B).
American Psychological Association (APA)
Barlow, Ashley P.& He, Jane& Tian, Cindy& Jeffery, Peter& Mason, Stephen C.& Tai, Bao-Jun…[et al.]. 2012. A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices. International Journal of Dentistry،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-506243
Modern Language Association (MLA)
Barlow, Ashley P.…[et al.]. A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices. International Journal of Dentistry No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-506243
American Medical Association (AMA)
Barlow, Ashley P.& He, Jane& Tian, Cindy& Jeffery, Peter& Mason, Stephen C.& Tai, Bao-Jun…[et al.]. A Comparative Evaluation of the Efficacy of Two Novel Desensitising Dentifrices. International Journal of Dentistry. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-506243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506243