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Evaluation of Acute Locoregional Toxicity in Patients with Breast Cancer Treated with Adjuvant Radiotherapy in Combination with Pazopanib
Joint Authors
Khan, Atif J.
Goyal, Sharad
Haffty, Bruce G.
Shah, Sneha
Danish, Hasan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-06
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
The purpose of this study was to analyze acute locoregional toxicity in patients with breast cancer receiving concurrent pazopanib and RT.
Materials and Methods.
Patients with breast cancer who received pazopanib in combination with radiation were identified and matched (2 : 1) to patients with breast cancer who did not receive pazopanib by use of chemotherapy, radiation field design, and radiation dose.
Toxicity was scored by the Common Terminology Criteria for Adverse Events and statistical analysis was performed.
Results.
Grade 1 or 2 radiation dermatitis was seen in 100% and 84% of pazopanib and RT patients and matched controls respectively (P = NS).
None of the patients receiving pazopanib and RT experienced ≥ grade 3 toxicity within the irradiated volume; three (16%) matched patients experienced a grade 3 skin reaction (P = 0.05).
Interestingly, grade 1 or 2 hyperpigmentation was seen in 17% of pazopanib and RT patients and 60% of matched controls (P = 0.005).
Conclusion.
The addition of concurrent pazopanib and RT when treating the intact breast, chest wall, and associated nodal regions in breast cancer seems to be safe and well tolerated.
American Psychological Association (APA)
Goyal, Sharad& Shah, Sneha& Khan, Atif J.& Danish, Hasan& Haffty, Bruce G.. 2012. Evaluation of Acute Locoregional Toxicity in Patients with Breast Cancer Treated with Adjuvant Radiotherapy in Combination with Pazopanib. ISRN Oncology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-506251
Modern Language Association (MLA)
Goyal, Sharad…[et al.]. Evaluation of Acute Locoregional Toxicity in Patients with Breast Cancer Treated with Adjuvant Radiotherapy in Combination with Pazopanib. ISRN Oncology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-506251
American Medical Association (AMA)
Goyal, Sharad& Shah, Sneha& Khan, Atif J.& Danish, Hasan& Haffty, Bruce G.. Evaluation of Acute Locoregional Toxicity in Patients with Breast Cancer Treated with Adjuvant Radiotherapy in Combination with Pazopanib. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-506251
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506251