APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease
Joint Authors
Barnholtz-Sloan, Jill
Land, Susan
Severson, Richard K.
Kato, Ikuko
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-18
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Dysfunctional lipid metabolism plays a central role in pathogenesis of major chronic diseases, and genetic factors are important determinants of individual lipid profiles.
We analyzed the associations of two well-established functional polymorphisms (FABP2 A54T and APOE isoforms) with past and family histories of 1492 population samples.
FABP2-T54 allele was associated with an increased risk of past history of myocardial infarction (odds ratio (OR) = 1.51).
Likewise, the subjects with APOE4, compared with E2 and E3, had a significantly increased risk of past history myocardial infarction (OR = 1.89).
The OR associated with APOE4 was specifically increased in women for past history of myocardial infarction but decreased for gallstone disease.
Interactions between gender and APOE isoforms were also significant or marginally significant for these two conditions.
FABP2-T54 allele may be a potential genetic marker for myocardial infarction, and APOE4 may exert sex-dependent effects on myocardial infarction and gallbladder disease.
American Psychological Association (APA)
Kato, Ikuko& Land, Susan& Barnholtz-Sloan, Jill& Severson, Richard K.. 2011. APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease. Cholesterol،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-506266
Modern Language Association (MLA)
Kato, Ikuko…[et al.]. APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease. Cholesterol No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-506266
American Medical Association (AMA)
Kato, Ikuko& Land, Susan& Barnholtz-Sloan, Jill& Severson, Richard K.. APOE and FABP2 Polymorphisms and History of Myocardial Infarction, Stroke, Diabetes, and Gallbladder Disease. Cholesterol. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-506266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506266