Early Death in Two Patients with Acute Promyelocytic Leukemia Presenting the bcr3 Isoform, FLT3-ITD Mutation, and Elevated WT1 Level
Joint Authors
Vacca, Adriana
Ledda, Antonio
Caocci, Giovanni
Arras, Marcella
Greco, Marianna
Celeghini, Ivana
La Nasa, Giorgio
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-07
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Despite major advances in the treatment of acute promyelocytic leukemia (APL), the problem of early death (ED) remains unsolved.
Alongside the currently known clinical and hematological risk factors, prognostic significance has been attributed to internal tandem duplication mutations of the fms-like tyrosine kinase-3 (FLT3-ITD), hypogranular variant morphology, and the bcr-3 isoform of PML-RARα.
We describe premature death of two patients with the hypogranular variant of APL who presented remarkably high expression levels of Wilms' tumor gene (WT1).
Our results point to WT1 as an important prognostic factor of ED that needs to be promptly evaluated in all newly diagnosed cases of APL.
American Psychological Association (APA)
Greco, Marianna& Caocci, Giovanni& Ledda, Antonio& Vacca, Adriana& Arras, Marcella& Celeghini, Ivana…[et al.]. 2013. Early Death in Two Patients with Acute Promyelocytic Leukemia Presenting the bcr3 Isoform, FLT3-ITD Mutation, and Elevated WT1 Level. Case Reports in Hematology،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-506270
Modern Language Association (MLA)
Greco, Marianna…[et al.]. Early Death in Two Patients with Acute Promyelocytic Leukemia Presenting the bcr3 Isoform, FLT3-ITD Mutation, and Elevated WT1 Level. Case Reports in Hematology No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-506270
American Medical Association (AMA)
Greco, Marianna& Caocci, Giovanni& Ledda, Antonio& Vacca, Adriana& Arras, Marcella& Celeghini, Ivana…[et al.]. Early Death in Two Patients with Acute Promyelocytic Leukemia Presenting the bcr3 Isoform, FLT3-ITD Mutation, and Elevated WT1 Level. Case Reports in Hematology. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-506270
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506270
