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An Efficient Apparatus for Rapid Deoxygenation of Erythrocyte Concentrates for Alternative Banking Strategies
Joint Authors
Zolla, Lello
D'Alessandro, Angelo
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Erythrocyte concentrates (ECs) stored for transfusion purposes still represent a lifesaving solution in a wide series of clinically occurring circumstances, especially for traumatized and perioperative patients.
However, concerns still arise and persist as to whether current criteria for collection and storage of ECs might actually represent the best case scenario or there might rather be still room for improvement.
In particular, the prolonged storage of EC has been associated with the accumulation of a wide series of storage lesions, either reversible (metabolism) or irreversible (protein and morphology).
Independent laboratories have contributed to propose alternative strategies, among which is the introduction of oxygen removal treatments to ECs.
Convincing biochemical and preliminary clinical evidences have been produced about the benefits derived from the introduction of this practice.
We, hereby, propose a rapid, efficient, and time-effective strategy for blood deoxygenation which might fit in current EC production chain.
The proposed strategy resulted in the complete deoxygenation of red blood cell hemoglobin (pO2<0.0021 mmHg).
A preliminary small-scale study about the application of the present method resulted in reduced hemolysis, decreased vesiculation, and limited alterations to the red blood cell morphology, as gleaned from flow cytometry and scanning electron microscopic analyses.
Further in-depth and larger-scale investigations are encouraged.
American Psychological Association (APA)
Zolla, Lello& D'Alessandro, Angelo. 2013. An Efficient Apparatus for Rapid Deoxygenation of Erythrocyte Concentrates for Alternative Banking Strategies. Journal of Blood Transfusion،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506295
Modern Language Association (MLA)
Zolla, Lello& D'Alessandro, Angelo. An Efficient Apparatus for Rapid Deoxygenation of Erythrocyte Concentrates for Alternative Banking Strategies. Journal of Blood Transfusion No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-506295
American Medical Association (AMA)
Zolla, Lello& D'Alessandro, Angelo. An Efficient Apparatus for Rapid Deoxygenation of Erythrocyte Concentrates for Alternative Banking Strategies. Journal of Blood Transfusion. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506295