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Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions
Joint Authors
Takeda, Kozue
Nakashima, Izumi
Kawamoto, Yoshiyuki
Kato, Masashi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Recent observations on environment-linked control of genetically prescribed signaling systems for either cell activation or cell death have been reviewed with a focus on the regulation of activities of protein tyrosine kinases (PTKs).
The environment-linked redox reactions seem to primarily affect cell surface receptors and cell membrane lipid rafts, and they induce generation of reactive oxygen species (ROS) in cells.
ROS thus generated might upregulate the catalytic activities of PTKs through inactivating protein tyrosine phosphatases that dephosphorylate and inactivate autophosphorylated PTKs.
Recent evidence has, however, demonstrated that ROS could also directly oxidize SH groups of genetically conserved specific cysteines on PTKs, sometimes producing disulfide-bonded dimers of PTK proteins, either for upregulation or downregulation of their catalytic activities.
The basic role of the redox reaction/covalent bond-mediated modification of protein tertiary structure-linked noncovalent bond-oriented signaling systems in living organisms is discussed.
American Psychological Association (APA)
Nakashima, Izumi& Kawamoto, Yoshiyuki& Takeda, Kozue& Kato, Masashi. 2011. Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions. Enzyme Research،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506296
Modern Language Association (MLA)
Nakashima, Izumi…[et al.]. Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions. Enzyme Research No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-506296
American Medical Association (AMA)
Nakashima, Izumi& Kawamoto, Yoshiyuki& Takeda, Kozue& Kato, Masashi. Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions. Enzyme Research. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-506296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506296