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The Extracts of Some Marine Invertebrates and Algae Collected off the Coast Waters of Vietnam Induce the Inhibitory Effects on the Activator Protein-1 Transcriptional Activity in JB6 Cl41 Cells
Joint Authors
Shubina, Larisa K.
Minh, C. V.
Krasokhin, V. B.
Fedorov, Sergey N.
Dyshlovoy, Sergey A.
Nam, N. H.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
It has previously been shown that inhibition of the transcriptional activity of the oncogenic nuclear factor AP-1 can result in cancer prevention.
Marine invertebrates and alga are a rich source of natural compounds that possess various biological activities.
The inhibitory effects of the extracts of Vietnamese marine organisms in relation to the AP-1 transcriptional activity were examined by the luciferase method using JB6 Cl41 cells stably expressing a luciferase reporter gene controlled by AP-1 DNA binding sequence.
As was found, 71 species of marine sponges out of 148 species studied contain inhibitors of the AP-1 transcriptional activity.
Therefore, marine organisms as a source of biologically active compounds have a great potential for isolation of the new cancer preventive compounds that inhibit the oncogenic AP-1 nuclear factor.
American Psychological Association (APA)
Fedorov, Sergey N.& Krasokhin, V. B.& Shubina, Larisa K.& Dyshlovoy, Sergey A.& Nam, N. H.& Minh, C. V.. 2013. The Extracts of Some Marine Invertebrates and Algae Collected off the Coast Waters of Vietnam Induce the Inhibitory Effects on the Activator Protein-1 Transcriptional Activity in JB6 Cl41 Cells. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-506301
Modern Language Association (MLA)
Fedorov, Sergey N.…[et al.]. The Extracts of Some Marine Invertebrates and Algae Collected off the Coast Waters of Vietnam Induce the Inhibitory Effects on the Activator Protein-1 Transcriptional Activity in JB6 Cl41 Cells. Journal of Chemistry No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-506301
American Medical Association (AMA)
Fedorov, Sergey N.& Krasokhin, V. B.& Shubina, Larisa K.& Dyshlovoy, Sergey A.& Nam, N. H.& Minh, C. V.. The Extracts of Some Marine Invertebrates and Algae Collected off the Coast Waters of Vietnam Induce the Inhibitory Effects on the Activator Protein-1 Transcriptional Activity in JB6 Cl41 Cells. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-506301
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506301