Selective Determinants of Low Bone Mineral Mass in Adult Women with Anorexia Nervosa

Joint Authors

Rizzoli, René
Graf, Jean-Daniel
Trombetti, Andrea
Richert, Laura
Chevalley, Thierry
Herrmann, François R.

Source

International Journal of Endocrinology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-03-24

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

We investigated the relative effect of amenorrhea and insulin-like growth factor-I (sIGF-I) levels on cancellous and cortical bone density and size.

We investigated 66 adult women with anorexia nervosa.

Lumbar spine and proximal femur bone mineral density was measured by DXA.

We calculated bone mineral apparent density.

Structural geometry of the spine and the hip was determined from DXA images.

Weight and BMI, but not height, as well as bone mineral content and density, but not area and geometry parameters, were lower in patients with anorexia nervosa as compared with the control group.

Amenorrhea, disease duration, and sIGF-I were significantly associated with lumbar spine and proximal femur BMD.

In a multiple regression model, we found that sIGF-I was the only significant independent predictor of proximal femur BMD, while duration of amenorrhea was the only factor associated with lumbar spine BMD.

Finally, femoral neck bone mineral apparent density, but not hip geometry variables, was correlated with sIGF-I.

In anorexia nervosa, spine BMD was related to hypogonadism, whereas sIGF-I predicted proximal femur BMD.

The site-specific effect of sIGF-I could be related to reduced volumetric BMD rather than to modified hip geometry.

American Psychological Association (APA)

Trombetti, Andrea& Richert, Laura& Herrmann, François R.& Chevalley, Thierry& Graf, Jean-Daniel& Rizzoli, René. 2013. Selective Determinants of Low Bone Mineral Mass in Adult Women with Anorexia Nervosa. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-506362

Modern Language Association (MLA)

Trombetti, Andrea…[et al.]. Selective Determinants of Low Bone Mineral Mass in Adult Women with Anorexia Nervosa. International Journal of Endocrinology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-506362

American Medical Association (AMA)

Trombetti, Andrea& Richert, Laura& Herrmann, François R.& Chevalley, Thierry& Graf, Jean-Daniel& Rizzoli, René. Selective Determinants of Low Bone Mineral Mass in Adult Women with Anorexia Nervosa. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-506362

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-506362