Controversies and Recent Advances in Hematopoietic Cell Transplantation for Follicular Non-Hodgkin Lymphoma
Joint Authors
Kanate, Abraham S.
Kharfan-Dabaja, Mohamed A.
Hamadani, Mehdi
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Commonly designated as an indolent non-Hodgkin lymphoma, follicular lymphoma (FL) presents with striking pathobiological and clinical heterogeneity.
Initial management strategies for FL have evolved to involve combination chemoimmunotherapy and/or radio-immunoconjugates.
Unfortunately even with the best available nontransplant treatment, which nowadays results in higher frequency of response, FL remains incurable.
Although considered a feasible therapeutic option, the use of hematopoietic cell transplantation (HCT) remains controversial.
The appropriate timing, graft source, and intensity of HCT conditioning regimens in FL are often matters of debate.
Herein we review the available published data pertaining to the use of autologous or allogeneic HCT in patients with FL across different stages of the disease, discuss major recent advances in the field, and highlight avenues for future research.
The current literature does not support a role of HCT for FL in first remission, but in the relapsed setting autologous HCT remains appropriate for patients with early chemosensitive relapses, while allogeneic transplantation remains the sole curative modality for this disease, in relatively younger patients without significant comorbidities.
American Psychological Association (APA)
Kanate, Abraham S.& Kharfan-Dabaja, Mohamed A.& Hamadani, Mehdi. 2012. Controversies and Recent Advances in Hematopoietic Cell Transplantation for Follicular Non-Hodgkin Lymphoma. Bone Marrow Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-506366
Modern Language Association (MLA)
Kanate, Abraham S.…[et al.]. Controversies and Recent Advances in Hematopoietic Cell Transplantation for Follicular Non-Hodgkin Lymphoma. Bone Marrow Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-506366
American Medical Association (AMA)
Kanate, Abraham S.& Kharfan-Dabaja, Mohamed A.& Hamadani, Mehdi. Controversies and Recent Advances in Hematopoietic Cell Transplantation for Follicular Non-Hodgkin Lymphoma. Bone Marrow Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-506366
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506366