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Cytotoxicity of Portuguese Propolis : The Proximity of the In Vitro Doses for Tumor and Normal Cell Lines
Joint Authors
Calhelha, Ricardo C.
Vilas-Boas, Miguel
Ferreira, Isabel C. F. R.
Queiroz, Maria-João R. P.
Falcão, Soraia
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
With a complex chemical composition rich in phenolic compounds, propolis (resinous substance collected by Apis mellifera from various tree buds) exhibits a broad spectrum of biological activities.
Recently, in vitro and in vivo data suggest that propolis has anticancer properties, but is the cytoxicity of propolis specific for tumor cells? To answer this question, the cytotoxicity of phenolic extracts from Portuguese propolis of different origins was evaluated using human tumor cell lines (MCF7—breast adenocarcinoma, NCI-H460—non-small cell lung carcinoma, HCT15—colon carcinoma, HeLa—cervical carcinoma, and HepG2—hepatocellular carcinoma), and non-tumor primary cells (PLP2).
The studied propolis presented high cytotoxic potential for human tumor cell lines, mostly for HCT15.
Nevertheless, excluding HCT15 cell line, the extracts at the GI50 obtained for tumor cell lines showed, in general, cytotoxicity for normal cells (PLP2).
Propolis phenolic extracts comprise phytochemicals that should be further studied for their bioactive properties against human colon carcinoma.
In the other cases, the proximity of the in vitro cytotoxic doses for tumor and normal cell lines should be confirmed by in vivo tests and may highlight the need for selection of specific compounds within the propolis extract.
American Psychological Association (APA)
Calhelha, Ricardo C.& Falcão, Soraia& Queiroz, Maria-João R. P.& Vilas-Boas, Miguel& Ferreira, Isabel C. F. R.. 2014. Cytotoxicity of Portuguese Propolis : The Proximity of the In Vitro Doses for Tumor and Normal Cell Lines. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-506379
Modern Language Association (MLA)
Calhelha, Ricardo C.…[et al.]. Cytotoxicity of Portuguese Propolis : The Proximity of the In Vitro Doses for Tumor and Normal Cell Lines. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-506379
American Medical Association (AMA)
Calhelha, Ricardo C.& Falcão, Soraia& Queiroz, Maria-João R. P.& Vilas-Boas, Miguel& Ferreira, Isabel C. F. R.. Cytotoxicity of Portuguese Propolis : The Proximity of the In Vitro Doses for Tumor and Normal Cell Lines. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-506379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506379