Improved Candidate Drug Mining for Alzheimer’s Disease
Joint Authors
Chang, Hsueh-Wei
Chuang, Li-Yeh
Cheng, Yu-Huei
Yang, Cheng-Hong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Alzheimer's disease (AD) is the main cause of dementia for older people.
Although several antidementia drugs such as donepezil, rivastigmine, galantamine, and memantine have been developed, the effectiveness of AD drug therapy is still far from satisfactory.
Recently, the single nucleotide polymorphisms (SNPs) have been chosen as one of the personalized medicine markers.
Many pharmacogenomics databases have been developed to provide comprehensive information by associating SNPs with drug responses, disease incidence, and genes that are critical in choosing personalized therapy.
However, we found that some information from different sets of pharmacogenomics databases is not sufficient and this may limit the potential functions for pharmacogenomics.
To address this problem, we used approximate string matching method and data mining approach to improve the searching of pharmacogenomics database.
After computation, we can successfully identify more genes linked to AD and AD-related drugs than previous online searching.
These improvements may help to improve the pharmacogenomics of AD for personalized medicine.
American Psychological Association (APA)
Cheng, Yu-Huei& Chuang, Li-Yeh& Chang, Hsueh-Wei& Yang, Cheng-Hong. 2014. Improved Candidate Drug Mining for Alzheimer’s Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-506409
Modern Language Association (MLA)
Cheng, Yu-Huei…[et al.]. Improved Candidate Drug Mining for Alzheimer’s Disease. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-506409
American Medical Association (AMA)
Cheng, Yu-Huei& Chuang, Li-Yeh& Chang, Hsueh-Wei& Yang, Cheng-Hong. Improved Candidate Drug Mining for Alzheimer’s Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-506409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506409