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Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists
Joint Authors
Bassaganya-Riera, Josep
Guri, Amir J.
Hontecillas, Raquel
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The prevalence of obesity and its associated comorbidities has grown to epidemic proportions in the US and worldwide.
Thus, developing safe and effective therapeutic approaches against these widespread and debilitating diseases is important and timely.
Activation of peroxisome proliferator-activated receptors (PPARs) α, γ, and δ through several classes of pharmaceuticals can prevent or treat a variety of metabolic and inflammatory diseases, including type II diabetes (T2D).
Thus, PPARs represent important molecular targets for developing novel and better treatments for a wide range of debilitating and widespread obesity-related diseases and disorders.
However, available PPAR γ agonistic drugs such as Avandia have significant adverse side effects, including weight gain, fluid retention, hepatotoxicity, and congestive heart failure.
An alternative to synthetic agonists of PPAR γ is the discovery and development of naturally occurring and safer nutraceuticals that may be dual or pan PPAR agonists.
The purpose of this paper is to summarize the health effects of three plant-derived PPAR agonists: abscisic acid (ABA), punicic acid (PUA), and catalpic acid (CAA) in the prevention and treatment of chronic inflammatory and metabolic diseases and disorders.
American Psychological Association (APA)
Bassaganya-Riera, Josep& Guri, Amir J.& Hontecillas, Raquel. 2010. Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists. Journal of Obesity،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-506420
Modern Language Association (MLA)
Bassaganya-Riera, Josep…[et al.]. Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists. Journal of Obesity No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-506420
American Medical Association (AMA)
Bassaganya-Riera, Josep& Guri, Amir J.& Hontecillas, Raquel. Treatment of Obesity-Related Complications with Novel Classes of Naturally Occurring PPAR Agonists. Journal of Obesity. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-506420
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506420