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Relationship between Younger Age, Autoimmunity, Cardiometabolic Risk, Oxidative Stress, HAART, and Ischemic Stroke in Africans with HIVAIDS
Joint Authors
Longokolo Mashi, Murielle
Nge Okwe, Augustin
Ellenga-Mbolla, Bertrand
Longo-Mbenza, Benjamin
Lelo Tshikwela, Michel
Mokondjimobe, Etienne
Mbungu Fuele, Simon
Gombet, Thierry
Kangola Kabangu, Nelly
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background and Purpose.
It now appears clear that both HIV/AIDS and antiretroviral therapy (HAART) use are associated with higher risk of cardiovascular disease such as stroke.
In this study, we evaluated the prevalence, the risk factors, and the cardiometabolic comorbidities of stroke in HIV/AIDS Central African patients.
Methods.
This hospital-based cross-sectional study collected clinical, laboratory, and imaging data of black Central African heterosexual, intravenous drug nonuser, and HIV/AIDS patients.
Results.
There were 54 men and 62 women, with a female to male ratio of 1.2 : 1.
All were defined by hypercoagulability and oxidative stress.
Hemorrhagic stroke was reported in 1 patient, ischemic stroke in 17 patients, and all stroke subtypes in 18 patients (15%).
Younger age <45 years (P=.003), autoimmunity (P<.0001), and metabolic syndrome defined by IDF criteria (P<.0001) were associated with ischemic stroke.
Conclusions.
Clustering of several cardiometabolic factors, autoimmunity, oxidative stress, and lifestyle changes may explain accelerated atherosclerosis and high risk of stroke in these young black Africans with HIV/AIDS.
Prevention and intervention programs are needed.
American Psychological Association (APA)
Longo-Mbenza, Benjamin& Longokolo Mashi, Murielle& Lelo Tshikwela, Michel& Mokondjimobe, Etienne& Gombet, Thierry& Ellenga-Mbolla, Bertrand…[et al.]. 2011. Relationship between Younger Age, Autoimmunity, Cardiometabolic Risk, Oxidative Stress, HAART, and Ischemic Stroke in Africans with HIVAIDS. ISRN Cardiology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-506423
Modern Language Association (MLA)
Longo-Mbenza, Benjamin…[et al.]. Relationship between Younger Age, Autoimmunity, Cardiometabolic Risk, Oxidative Stress, HAART, and Ischemic Stroke in Africans with HIVAIDS. ISRN Cardiology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-506423
American Medical Association (AMA)
Longo-Mbenza, Benjamin& Longokolo Mashi, Murielle& Lelo Tshikwela, Michel& Mokondjimobe, Etienne& Gombet, Thierry& Ellenga-Mbolla, Bertrand…[et al.]. Relationship between Younger Age, Autoimmunity, Cardiometabolic Risk, Oxidative Stress, HAART, and Ischemic Stroke in Africans with HIVAIDS. ISRN Cardiology. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-506423
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506423