Cadmium and Its Neurotoxic Effects
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Cadmium (Cd) is a heavy metal that has received considerable concern environmentally and occupationally.
Cd has a long biological half-life mainly due to its low rate of excretion from the body.
Thus, prolonged exposure to Cd will cause toxic effect due to its accumulation over time in a variety of tissues, including kidneys, liver, central nervous system (CNS), and peripheral neuronal systems.
Cd can be uptaken from the nasal mucosa or olfactory pathways into the peripheral and central neurons; for the latter, Cd can increase the blood brain barrier (BBB) permeability.
However, mechanisms underlying Cd neurotoxicity remain not completely understood.
Effect of Cd neurotransmitter, oxidative damage, interaction with other metals such as cobalt and zinc, estrogen-like, effect and epigenetic modification may all be the underlying mechanisms.
Here, we review the in vitro and in vivo evidence of neurotoxic effects of Cd.
The available finding indicates the neurotoxic effects of Cd that was associated with both biochemical changes of the cell and functional changes of central nervous system, suggesting that neurotoxic effects may play a role in the systemic toxic effects of the exposure to Cd, particularly the long-term exposure.
American Psychological Association (APA)
Wang, Bo& Du, Yanli. 2013. Cadmium and Its Neurotoxic Effects. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-506431
Modern Language Association (MLA)
Wang, Bo& Du, Yanli. Cadmium and Its Neurotoxic Effects. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-506431
American Medical Association (AMA)
Wang, Bo& Du, Yanli. Cadmium and Its Neurotoxic Effects. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-506431
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506431