The 14 bp DelIns HLA-G Polymorphism Is Related with High Blood Pressure in Acute Coronary Syndrome and Type 2 Diabetes Mellitus

Abstract EN

Immunologic and inflammatory processes are involved in the pathogenesis of acute coronary syndrome (ACS) and type 2 diabetes mellitus (DM2).

Human leukocyte antigen-G (HLA-G) is a negative regulator of the immune response.

This study evaluates the 14 bp Del/Ins HLA-G polymorphism in ACS and DM2.

Three hundred and seventy individuals from Western Mexico were recruited and categorized into three groups: ACS (86), DM2 without coronary complications (70), and healthy subjects (214).

Genotyping of the 14 bp Del/Ins HLA-G polymorphism was performed by PCR and Native-PAGE.

The most common risk factors were hypertension and overweight in ACS and DM2, respectively.

The genetic distribution of the 14 bp Del/Ins HLA-G polymorphism showed no significant differences between groups (P≥0.23).

Nonetheless, the Ins/Ins genotype was associated with high blood pressure (HBP) in the DM2 group (ORc = 1.65, P=0.02).

The genetic recessive model showed similar findings (ORc = 3.03, P=0.04).

No association was found in ACS, with a P of 0.05; nevertheless, the prevalence of Ins/Ins carriers was quite similar to that found in the DM2-HBP group.

The 14 bp Del/Ins HLA-G polymorphism was not a susceptibility factor for ACS or DM2; however, the Ins/Ins genotype might have contributed to the development of HBP in the studied groups.