Immunogenicity Studies in Carnivores Using a Rabies Virus Construct with a Site-Directed Deletion in the Phosphoprotein
Joint Authors
Vos, Ad
Conzelmann, Karl-Klaus
Neubert, Andreas
Teifke, Jens
Fooks, Anthony R.
Finke, Stefan
Müller, Thomas
Source
Advances in Preventive Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-21
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Different approaches have been applied to develop highly attenuated rabies virus vaccines for oral vaccination of mesocarnivores.
One prototype vaccine construct is SAD dIND1, which contains a deletion in the P-gene severely limiting the inhibition of type-1 interferon induction.
Immunogenicity studies in foxes and skunks were undertaken to investigate whether this highly attenuated vaccine would be more immunogenic than the parental SAD B19 vaccine strain.
In foxes, it was demonstrated that SAD dIND1 protected the animals against a rabies infection after a single oral dose, although virus neutralizing antibody titres were lower than in foxes orally vaccinated with the SAD B19 virus as observed in previous experiments.
In contrast, skunks receiving 107.5 FFU SAD dIND1 did not develop virus neutralizing antibodies and were not protected against a subsequent rabies infection.
American Psychological Association (APA)
Vos, Ad& Conzelmann, Karl-Klaus& Finke, Stefan& Müller, Thomas& Teifke, Jens& Fooks, Anthony R.…[et al.]. 2011. Immunogenicity Studies in Carnivores Using a Rabies Virus Construct with a Site-Directed Deletion in the Phosphoprotein. Advances in Preventive Medicine،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-506449
Modern Language Association (MLA)
Vos, Ad…[et al.]. Immunogenicity Studies in Carnivores Using a Rabies Virus Construct with a Site-Directed Deletion in the Phosphoprotein. Advances in Preventive Medicine No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-506449
American Medical Association (AMA)
Vos, Ad& Conzelmann, Karl-Klaus& Finke, Stefan& Müller, Thomas& Teifke, Jens& Fooks, Anthony R.…[et al.]. Immunogenicity Studies in Carnivores Using a Rabies Virus Construct with a Site-Directed Deletion in the Phosphoprotein. Advances in Preventive Medicine. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-506449
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506449