Interaction of Carbamazepine with Herbs, Dietary Supplements, and Food : A Systematic Review
Joint Authors
Gao, Qiong
Zuo, Zhong
Fong, Sophia Yui Kau
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Background.
Carbamazepine (CBZ) is a first-line antiepileptic drug which may be prone to drug interactions.
Systematic review of herb- and food-drug interactions on CBZ is warranted to provide guidance for medical professionals when prescribing CBZ.
Method.
A systematic review was conducted on six English databases and four Chinese databases.
Results.
196 out of 3179 articles fulfilled inclusion criteria, of which 74 articles were reviewed and 33 herbal products/dietary supplement/food interacting with CBZ were identified.
No fatal or severe interactions were documented.
The majority of the interactions were pharmacokinetic-based (80%).
Traditional Chinese medicine accounted for most of the interactions (n=17), followed by food (n=10), dietary supplements (n=3), and other herbs/botanicals (n=3).
Coadministration of 11 and 12 of the studied herbal products/dietary supplement/food significantly decreased or increased the plasma concentrations of CBZ.
Regarding pharmacodynamic interaction, Xiao-yao-san, melatonin, and alcohol increased the side effects of CBZ while caffeine lowered the antiepileptic efficacy of CBZ.
Conclusion.
This review provides a comprehensive summary of the documented interactions between CBZ and herbal products/food/dietary supplements which assists healthcare professionals to identify potential herb-drug and food-drug interactions, thereby preventing potential adverse events and improving patients’ therapeutic outcomes when prescribing CBZ.
American Psychological Association (APA)
Fong, Sophia Yui Kau& Gao, Qiong& Zuo, Zhong. 2013. Interaction of Carbamazepine with Herbs, Dietary Supplements, and Food : A Systematic Review. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-506460
Modern Language Association (MLA)
Fong, Sophia Yui Kau…[et al.]. Interaction of Carbamazepine with Herbs, Dietary Supplements, and Food : A Systematic Review. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-506460
American Medical Association (AMA)
Fong, Sophia Yui Kau& Gao, Qiong& Zuo, Zhong. Interaction of Carbamazepine with Herbs, Dietary Supplements, and Food : A Systematic Review. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-506460
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506460